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CAVER 2.0 is a software tool for protein analysis leading to detection of channels. Channels are in fact void pathways leading from buried cavities to the outside solvent of a protein structure. Studying of these pathways is highly important in the area of drug design and molecular enzymology.

CAVER 2.0 provides rapid, accurate and fully automated calculation of channels not only for static molecules, but also for dynamic molecular simulations.

CAVER 2.0 facilitates analysis of any molecular structure including proteins, nucleic acids or inorganic materials.

CAVER 2.0 can be used in two possible ways. If you are accustomed with the PyMOL application, you can download the CAVER plugin for PyMOL. Then the standard functionality of PyMOL application for the subsequent exploration of computed channels can be used. The other possibility is to take advantage of our CAVER Viewer application, which has been designed exactly for the problem of detection and mainly for further exploration of channels. It includes the CAVER 2.0 algorithm for computation of channels in static molecule as well as in molecular dynamics. CAVER Viewer can be downloaded and installed as a standalone version or you can use the online version based on the Java Web Start technology.