Efficient RNA sequence manipulations (like multiple alignments) need to be constrained by rules of RNA structure folding. The structural knowledge has increased dramatically in the last years with the accumulation of several large RNA structures like those of the bacterial ribosome subunits. However, no tool in the RNA community provides an easy way to link and integrate progress made at the sequence level using the available three-dimensional information. S2S proposes a framework in which an user can easily display, manipulate, and interconnect heterogeneous RNA data like multiple sequence alignments, secondary and tertiary structures. S2S has been implemented with the Java language and has been developed and tested under UNIX systems like Linux and MacOSX. (From: http://bioinformatics.org/S2S/)
Check out the S2S Homepage.