File:PPIIMoL Fig7.jpg: Difference between revisions

Figure 7. Homo sapiens Anaplastic Leukemia Kinase (HsALK)

A. Primary structure of the fourteen PPII helices in HsALK. Helices are numbered according to the order along the sequence.

B. Schematic diagram representing the PPII helices as triangles. Connecting loops above the plane are shown as solid lines; those below the plane are shown as dotted lines. For clarity, the sequence of the connecting segments are not shown. PPII helical N-termini pointing up are outlined in red; N- termini pointing down are outlined in blue. PPII helices which two, three and four, five and six neighboring helices are shaded white, light gray, medium gray, dark gray and black respectively. PPII helices with 5 or 6 neighbors are labeled in white.

C. The tertiary structure of the PPII helical bundle domain of HsALK (PDB: 7N00) is shown end-on with helices colored in a rainbow spectrum from purple (helix 1) to dark red (helix 14).